Improved formulation of a recombinant ricin A-chain vaccine increases its stability and effective antigenicity.

@article{Carra2007ImprovedFO,
  title={Improved formulation of a recombinant ricin A-chain vaccine increases its stability and effective antigenicity.},
  author={John H. Carra and Robert W Wannemacher and Ralph F Tammariello and Changhong Y Lindsey and Richard E Dinterman and Rowena D Schokman and L. A. Smith},
  journal={Vaccine},
  year={2007},
  volume={25 21},
  pages={4149-58}
}
Ricin is a potent toxin associated with bioterrorism for which no vaccine or specific countermeasures are currently available. A stable, non-toxic and immunogenic recombinant ricin A-chain vaccine (RTA 1-33/44-198) has been developed by protein engineering. We identified optimal formulation conditions for this vaccine under which it remained stable and potent in storage for up to 18 months, and resisted multiple rounds of freeze-thawing without stabilizing co-solvents. Reformulation from… CONTINUE READING
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