Improved fecal DNA test for colorectal cancer screening.

  title={Improved fecal DNA test for colorectal cancer screening.},
  author={Steven H. Itzkowitz and Lina Jandorf and Randall E. Brand and Linda Rabeneck and Paul C. Schroy and Stephen J. Sontag and David Orville Johnson and Joel Skoletsky and Kris Durkee and Sanford Markowitz and Anthony P Shuber},
  journal={Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association},
  volume={5 1},
BACKGROUND & AIMS Fecal DNA testing has shown greater sensitivity than guaiac-based occult blood tests for noninvasive colorectal cancer (CRC) screening. The prototype assay (version 1), which analyzed 22 gene mutations and DNA integrity assay (DIA), showed a sensitivity of 52% for CRC detection and a specificity of 94% in average-risk individuals. The present study was conducted to determine the sensitivity and specificity of a second-generation assay (version 2) that uses improved DNA… CONTINUE READING

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