Improved expression in hematopoietic and lymphoid cells in mice after transplantation of bone marrow transduced with a modified retroviral vector.

@article{Halene1999ImprovedEI,
  title={Improved expression in hematopoietic and lymphoid cells in mice after transplantation of bone marrow transduced with a modified retroviral vector.},
  author={Stephanie Halene and Lei Wang and Richard M. Cooper and David Bockstoce and Paul B. Robbins and Donald B Kohn},
  journal={Blood},
  year={1999},
  volume={94 10},
  pages={3349-57}
}
Retroviral vectors based on the Moloney murine leukemia virus (MoMuLV) are currently the most commonly used vehicles for stable gene transfer into mammalian hematopoietic cells. But, even with reasonable transduction efficiency, expression only occurs in a low percentage of transduced cells and decreases to undetectable levels over time. We have previously reported the modified MND LTR (myeloproliferative sarcoma virus enhancer, negative control region deleted, dl587rev primer-binding site… CONTINUE READING