Improved excitation light rejection enhances small-animal fluorescent optical imaging.

@article{Hwang2005ImprovedEL,
  title={Improved excitation light rejection enhances small-animal fluorescent optical imaging.},
  author={Kildong Hwang and Jessica P. Houston and John C. Rasmussen and Amit Joshi and Shi Ke and Chun Li and Eva M. Sevick-Muraca},
  journal={Molecular imaging},
  year={2005},
  volume={4 3},
  pages={194-204}
}
Small-animal fluorescence-enhanced imaging involves the detection of weak fluorescent signals emanating from nanomolar to picomolar concentrations of exogenous or endogenously produced fluorophore concurrent with the rejection of an overwhelmingly large component of backscattered excitation light. The elimination of the back-reflected excitation light of the collected signal remains a major and often unrecognized challenge for further reducing the noise floor and increasing sensitivity of small… CONTINUE READING

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