Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4.

@article{Lee2013ImprovedEV,
  title={Improved ex vivo expansion of adult hematopoietic stem cells by overcoming CUL4-mediated degradation of HOXB4.},
  author={Jennifer Inhae Lee and Jae-Hung Shieh and Jianxuan Zhang and Liren Liu and Yue Zhang and Jae Yong Eom and Giovanni Morrone and Malcolm A. S. Moore and Pengbo Zhou},
  journal={Blood},
  year={2013},
  volume={121 20},
  pages={4082-9}
}
Direct transduction of the homeobox (HOX) protein HOXB4 promotes the proliferation of hematopoietic stem cells (HSCs) without induction of leukemogenesis, but requires frequent administration to overcome its short protein half-life (∼1 hour). We demonstrate here that HOXB4 protein levels are post-translationally regulated by the CUL4 ubiquitin ligase, and define the degradation signal sequence (degron) of HOXB4 required for CUL4-mediated destruction. Additional HOX paralogs share the conserved… CONTINUE READING
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