Improved efficacy of stem cell labeling for magnetic resonance imaging studies by the use of cationic liposomes.

  title={Improved efficacy of stem cell labeling for magnetic resonance imaging studies by the use of cationic liposomes.},
  author={Ewout Jan van den Bos and Anja Wagner and Heiko Mahrholdt and Richard F. Thompson and Yoshihisa Morimoto and Brad S. Sutton and Robert M. Judd and Doris A Taylor},
  journal={Cell transplantation},
  volume={12 7},
Labeling stem cells with FDA-approved superparamagnetic iron oxide particles makes it possible to track cells in vivo with magnetic resonance imaging (MRI), but high intracellular levels of iron can cause free radical formation and cytotoxicity. We hypothesized that the use of cationic liposomes would increase labeling efficiency without toxic effects. Rabbit skeletal myoblasts were labeled with iron oxide by: 1) uptake of iron oxide incorporated into cationic transfection liposomes (group I… CONTINUE READING


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Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells

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