Improved efficacy of alphavbeta3-targeted albumin conjugates by conjugation of a novel auristatin derivative.

@article{Temming2007ImprovedEO,
  title={Improved efficacy of alphavbeta3-targeted albumin conjugates by conjugation of a novel auristatin derivative.},
  author={Kai Temming and Damon L. Meyer and Roger F Zabinski and Peter D. Senter and Klaas Poelstra and Grietje Molema and Robbert Jan Kok},
  journal={Molecular pharmaceutics},
  year={2007},
  volume={4 5},
  pages={686-94}
}
Cellular handling of drug delivery preparations en route to the lysosomal compartment has been extensively studied, but little is known about cellular handling of drugs subsequent to their release from the delivery system. We studied a series of closely related drug targeting conjugates, consisting of albumins equipped with alpha vbeta 3-selective RGD-peptide homing ligands, PEG stealth domains, and either the antitubulin agent monomethyl auristatin E (MMAE) or a new F-variant (MMAF). Since… CONTINUE READING

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