Improved efficacy of a novel anti-angiogenic drug combination (TL-118) against colorectal-cancer liver metastases; MRI monitoring in mice

  title={Improved efficacy of a novel anti-angiogenic drug combination (TL-118) against colorectal-cancer liver metastases; MRI monitoring in mice},
  author={Y. Edrei and E. Gross and N. Corchia and R. Abramovitch},
  journal={British Journal of Cancer},
  pages={658 - 666}
  • Y. Edrei, E. Gross, +1 author R. Abramovitch
  • Published 2012
  • Medicine
  • British Journal of Cancer
  • Background:The poor prognosis of patients with colorectal-cancer liver metastases (CRLM) and the insufficiency of available treatments have raised the need for alternative curative strategies. We aimed to assess the therapeutic potential of TL-118, a new anti-angiogenic drug combination, for CRLM treatment, in a mouse model.Methods:The therapeutic potential of TL-118 was evaluated and compared with B20-4.1.1 (B20; anti-VEGF antibody) and rapamycin in CRLM-bearing mice. Tumour progression and… CONTINUE READING
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