Improved diagnosis of mastocytosis by measurement of urinary histamine metabolites.

@article{Keyzer1983ImprovedDO,
  title={Improved diagnosis of mastocytosis by measurement of urinary histamine metabolites.},
  author={Jules J. Keyzer and Jan G R de Monchy and Jasper J. van Doormaal and Pieter C van Voorst Vader},
  journal={The New England journal of medicine},
  year={1983},
  volume={309 26},
  pages={
          1603-5
        }
}
In an attempt to facilitate the diagnosis of mastocytosis, we measured the urinary excretion of histamine and two of its main metabolites (N tau-methylhistamine and N tau-methylimidazoleacetic acid) in eight adults with this disorder. All patients had above-normal values for the metabolites of histamine, whereas only three had above-normal values for histamine. In both 24-hour and randomly voided urine specimens, the determination of histamine metabolites is more specific and sensitive for the… CONTINUE READING
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