Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus.

  title={Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus.},
  author={Scott J Rodig and Jingwei Cheng and Jacek Wardzala and Andrew A Dorosario and Jessica J Scanlon and Alvaro C. Laga and Alejandro Mart{\'i}nez-Fernandez and Justine A Barletta and Andrew M Bellizzi and Subhashini Sadasivam and Dustin T. Holloway and Dylan J Cooper and Thomas S Kupper and Linda C. Wang and James A. DeCaprio},
  journal={The Journal of clinical investigation},
  volume={122 12},
A human polyomavirus was recently discovered in Merkel cell carcinoma (MCC) specimens. The Merkel cell polyomavirus (MCPyV) genome undergoes clonal integration into the host cell chromosomes of MCC tumors and expresses small T antigen and truncated large T antigen. Previous studies have consistently reported that MCPyV can be detected in approximately 80% of all MCC tumors. We sought to increase the sensitivity of detection of MCPyV in MCC by developing antibodies capable of detecting large T… CONTINUE READING