Improved detection of differentially expressed genes through incorporation of gene locations.

@article{Xiao2009ImprovedDO,
  title={Improved detection of differentially expressed genes through incorporation of gene locations.},
  author={Guanghua Xiao and Cavan S Reilly and Arkady B. Khodursky},
  journal={Biometrics},
  year={2009},
  volume={65 3},
  pages={
          805-14
        }
}
In determining differential expression in cDNA microarray experiments, the expression level of an individual gene is usually assumed to be independent of the expression levels of other genes, but many recent studies have shown that a gene's expression level tends to be similar to that of its neighbors on a chromosome, and differentially expressed (DE) genes are likely to form clusters of similar transcriptional activity along the chromosome. When modeled as a one-dimensional spatial series, the… 
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