Improved detection and comparative sizing of human chromosomal telomeres in situ

  title={Improved detection and comparative sizing of human chromosomal telomeres in situ},
  author={Kateřina Krejci and J\orn Koch},
Telomeric length dynamics are thought to play an important role both in the processes of cellular aging and cancer progression. We have revised the primed in situ (PRINS) labeling technique to allow an estimation of the relative length of individual telomeres. We illustrate the applicability of the approach by demonstrating different telomeric sizes not only between blood lymphocytes from a young and an old donor, but also among bone marrow cells from hematological cancer patients. In the… CONTINUE READING

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