Improved coupling between proliferation-arrest and differentiation-induction in ML-1 human myeloblastic leukemia cells.

@article{Kozopas1990ImprovedCB,
  title={Improved coupling between proliferation-arrest and differentiation-induction in ML-1 human myeloblastic leukemia cells.},
  author={Karen M Kozopas and H L Buchan and Ruth W. Craig},
  journal={Journal of cellular physiology},
  year={1990},
  volume={145 3},
  pages={575-86}
}
Proliferation and differentiation are coupled in normal cells and are aberrant in leukemia cells. The studies reported here were aimed at more effectively coupling proliferation-arrest and differentiation-induction in a human myeloblastic leukemia cell line (ML-1). This was accomplished by using reduced serum conditions in conjunction with a differentiation-inducing agent: cells were first incubated in reduced serum [0.3% fetal bovine serum (FBS)] instead of standard conditions (7.5% FBS) and… CONTINUE READING

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