Improved correction for the tissue fraction effect in lung PET/CT imaging.

  title={Improved correction for the tissue fraction effect in lung PET/CT imaging.},
  author={Beverley F. Holman and Vesna Cuplov and Lynn Millner and Brian F. Hutton and Toby M Maher and Ashley M. Groves and Kris Thielemans},
  journal={Physics in medicine and biology},
  volume={60 18},
Recently, there has been an increased interest in imaging different pulmonary disorders using PET techniques. Previous work has shown, for static PET/CT, that air content in the lung influences reconstructed image values and that it is vital to correct for this 'tissue fraction effect' (TFE). In this paper, we extend this work to include the blood component and also investigate the TFE in dynamic imaging. CT imaging and PET kinetic modelling are used to determine fractional air and blood voxel… CONTINUE READING
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