Improved corneal wound healing through modulation of gap junction communication using connexin43-specific antisense oligodeoxynucleotides.

@article{Grupcheva2012ImprovedCW,
  title={Improved corneal wound healing through modulation of gap junction communication using connexin43-specific antisense oligodeoxynucleotides.},
  author={Christina N. Grupcheva and Wilda T Laux and Ilva Dana Rupenthal and Jennifer Jane McGhee and Charles N. J. McGhee and Colin Richard Green},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 3},
  pages={
          1130-8
        }
}
PURPOSE Gap junctions play a major role in corneal wound healing. This study used reproducible models of corneal wound healing to evaluate the effect of a gap junction channel modulator, connexin43 (Cx43) antisense oligodeoxynucleotides (AsODN), on corneal healing dynamics. METHODS A mechanical scrape wound model was used to evaluate Cx43 AsODN penetration and initial wound reepithelialization 12 hours postsurgery. Thereafter, detailed analyses of corneal edema, inflammation, and healing were… CONTINUE READING

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