Improved corneal bioavailability of ofloxacin: biodegradable microsphere-loaded ion-activated in situ gel delivery system

@inproceedings{Sayed2015ImprovedCB,
  title={Improved corneal bioavailability of ofloxacin: biodegradable microsphere-loaded ion-activated in situ gel delivery system},
  author={Elshaimaa G Sayed and Amal Kamal Hussein and Khaled Ali Khaled and Osama A A Ahmed},
  booktitle={Drug design, development and therapy},
  year={2015}
}
The aim of the study was to improve corneal penetration and bioavailability of ofloxacin (OFX) eye preparations. OFX was incorporated in poly (lactide-co-glycolide) as biodegradable microspheres using oil in oil emulsion solvent evaporation technique. The prepared OFX microspheres were then incorporated in Gelrite(®) in situ gel preparation. In addition, OFX Gelrite-based in situ gel formulations were prepared. OFX formulations were characterized for gelling capacity, viscosity, and rheological… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

The use of mucoadhesive polymers in ocular drug delivery.

  • Advanced drug delivery reviews
  • 2005
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

In situ-forming hydrogels for sustained ophthalmic drug delivery.

  • Journal of controlled release : official journal of the Controlled Release Society
  • 2007
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Dendrimers as versatile platform in drug delivery applications.

  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2009

Similar Papers

Loading similar papers…