Improved co-production of S-adenosylmethionine and glutathione using citrate as an auxiliary energy substrate.

@article{Wang2013ImprovedCO,
  title={Improved co-production of S-adenosylmethionine and glutathione using citrate as an auxiliary energy substrate.},
  author={Yulei Wang and Dahui Wang and Gongyuan Wei and Chengfu Wang},
  journal={Bioresource technology},
  year={2013},
  volume={131},
  pages={28-32}
}
The effects of sodium citrate on the fermentative co-production of S-adenosylmethionine (SAM) and glutathione (GSH) using Candida utilis CCTCC M 209298 were investigated. Sodium citrate was beneficial for the biosynthesis of SAM and GSH and in turn improved intracellular SAM and GSH contents. Adding 2 g/L of sodium citrate at 15 h was the most efficient approach for achieving elevated co-production of SAM and GSH. Using this sodium citrate addition mode, co-production of SAM and GSH reached 663… CONTINUE READING