Improved clonality analysis of multifocal bladder tumors by combination of histopathologic organ mapping, loss of heterozygosity, fluorescence in situ hybridization, and p53 analyses.

@article{Denzinger2006ImprovedCA,
  title={Improved clonality analysis of multifocal bladder tumors by combination of histopathologic organ mapping, loss of heterozygosity, fluorescence in situ hybridization, and p53 analyses.},
  author={Stefan Denzinger and Kristin Mohren and Ruth Knuechel and Peter J. Wild and Maximilian Burger and Wolf Ferdinand Wieland and Arndt Hartmann and Robert Franz St{\"o}hr},
  journal={Human pathology},
  year={2006},
  volume={37 2},
  pages={143-51}
}
The clonality status of multifocal bladder tumors is still controversially discussed with experimental evidence for both monoclonality and field cancerization. Methodologically, loss of heterozygosity (LOH) and genomic sequencing analyses are widely used in clonality analysis of malignant tumors. In the present study, we used LOH analysis and genomic sequencing in combination with fluorescence in situ hybridization (FISH) and extensive histopathologic whole-organ mapping to determine the clonal… CONTINUE READING
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