Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor.

@article{He2011ImprovedCA,
  title={Improved cellularization and angiogenesis using collagen scaffolds chemically conjugated with vascular endothelial growth factor.},
  author={Qifen He and Yannan Zhao and Bing Chen and Zhifeng Xiao and Jing Zhang and Lei Chen and Wei Chen and Feilong Deng and Jianwu Dai},
  journal={Acta biomaterialia},
  year={2011},
  volume={7 3},
  pages={1084-93}
}
Much research has focused on developing vascular endothelial growth factor (VEGF) delivery systems to enhance angiogenesis in wound repair and in tissue engineering. Collagen can be used as a delivery system because of its biocompatibility, but its fast degradation rate and limited affinity with growth factors are disadvantageous for maintaining a sufficient growth factor concentration at injury sites. To enhance VEGF binding to collagen scaffolds and reduce the collagen degradation rate we… CONTINUE READING
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Collagens. Cell Tissue Res 2009;339:247–57

  • MK Gordon, RA Hahn
  • 2009
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