Improved cellular and humoral immune responses against Mycobacterium tuberculosis antigens after intramuscular DNA immunisation combined with muscle electroporation.

@article{Tollefsen2002ImprovedCA,
  title={Improved cellular and humoral immune responses against Mycobacterium tuberculosis antigens after intramuscular DNA immunisation combined with muscle electroporation.},
  author={Stig Tollefsen and Torunn Tjelle and Joerg Schneider and Morten Harboe and Harald G. Wiker and Glyn R Hewinson and Kris Huygen and Iacob Mathiesen},
  journal={Vaccine},
  year={2002},
  volume={20 27-28},
  pages={3370-8}
}
New delivery methods are needed to improve the efficiency of existing DNA vaccines. We have measured the immune response to Mycobacterium tuberculosis antigens following intramuscular DNA injection in combination with or without electroporation. Three to 6-fold increase in the number of antigen specific CD4(+) and CD8(+) T cells, measured by IFN-gamma-producing cells in an ELISPOT assay, was found in mice DNA injected and electroporated compared with non-electroporated mice. Similarly, 5 to 10… CONTINUE READING
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