Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons.

@article{Sundberg2013ImprovedCT,
  title={Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons.},
  author={Maria Sundberg and Helle Bogetofte and Tristan Lawson and Johan Jansson and Gaynor A. Smith and Arnar Astradsson and Michele A Moore and Teresia M. Osborn and Oliver Daniel Cooper and Roger D. Spealman and Penelope J. Hallett and O. Isacson},
  journal={Stem cells},
  year={2013},
  volume={31 8},
  pages={1548-62}
}
The main motor symptoms of Parkinson's disease are due to the loss of dopaminergic (DA) neurons in the ventral midbrain (VM). For the future treatment of Parkinson's disease with cell transplantation it is important to develop efficient differentiation methods for production of human iPSCs and hESCs-derived midbrain-type DA neurons. Here we describe an efficient differentiation and sorting strategy for DA neurons from both human ES/iPS cells and non-human primate iPSCs. The use of non-human… CONTINUE READING
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