Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats.

@article{Chan2006ImprovedCF,
  title={Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats.},
  author={Vincent Chan and Andrew Hoey and Lindsay Brown},
  journal={British journal of pharmacology},
  year={2006},
  volume={148 7},
  pages={902-8}
}
The ability of aminoguanidine (AG), an inhibitor of collagen crosslinking, to prevent changes in cardiac and vascular structure and function has been determined in the deoxycorticosterone acetate (DOCA)-salt hypertensive rat as a model of the cardiovascular remodelling observed in chronic human hypertension. Uninephrectomized rats (UNX) administered DOCA (25 mg every fourth day s.c.) and 1% NaCl in drinking water for 28 days developed cardiovascular remodelling shown as systolic hypertension… CONTINUE READING
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