Improved brain delivery of a nonsteroidal anti-inflammatory drug with a synthetic glyceride ester: a preliminary attempt at a CNS drug delivery system for the therapy of Alzheimer's disease.

Abstract

1,3-Diacetyl-2-ketoprofen glyceride (DAKG), a prodrug of ketoprofen, was synthesized as a model compound in our attempt to develop a central nervous system (CNS) drug delivery system to treat Alzheimer's disease. The primary purpose of the present study is to test whether DAKG improves the delivery of ketoprofen to the brain and to quantitatively evaluate… (More)

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Cite this paper

@article{Deguchi2000ImprovedBD, title={Improved brain delivery of a nonsteroidal anti-inflammatory drug with a synthetic glyceride ester: a preliminary attempt at a CNS drug delivery system for the therapy of Alzheimer's disease.}, author={Y. Deguchi and H. Hayashi and S. Fujii and Tateaki Naito and Y. Yokoyama and S. Yamada and R. Kimura}, journal={Journal of drug targeting}, year={2000}, volume={8 6}, pages={371-81} }