Improved bone defect healing by a superagonistic GDF5 variant derived from a patient with multiple synostoses syndrome.


Multiple synostoses syndrome 2 (SYNS2) is a rare genetic disease characterized by multiple fusions of the joints of the extremities, like phalangeal joints, carpal and tarsal joints or the knee and elbows. SYNS2 is caused by point mutations in the Growth and Differentiation Factor 5 (GDF5), which plays an essential role during skeletal development and… (More)
DOI: 10.1016/j.bone.2014.12.017


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