Improved biocatalysts by directed evolution and rational protein design.

@article{Bornscheuer2001ImprovedBB,
  title={Improved biocatalysts by directed evolution and rational protein design.},
  author={Uwe T Bornscheuer and Martina Pohl},
  journal={Current opinion in chemical biology},
  year={2001},
  volume={5 2},
  pages={137-43}
}
The efficient application of biocatalysts requires the availability of suitable enzymes with high activity and stability under process conditions, desired substrate selectivity and high enantioselectivity. However, wild-type enzymes often need to be optimized to fulfill these requirements. Two rather contradictory tools can be used on a molecular level to create tailor-made biocatalysts: directed evolution and rational protein design. 

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