Improved bioactivity of G-rich triplex-forming oligonucleotides containing modified guanine bases.

@article{Rogers2014ImprovedBO,
  title={Improved bioactivity of G-rich triplex-forming oligonucleotides containing modified guanine bases.},
  author={Faye A. Rogers and Janice A. Lloyd and Meetu Kaushik Tiwari},
  journal={Artificial DNA, PNA & XNA},
  year={2014},
  volume={5 1},
  pages={
          e27792
        }
}
Triplex structures generated by sequence-specific triplex-forming oligonucleotides (TFOs) have proven to be promising tools for gene targeting strategies. In addition, triplex technology has been highly utilized to study the molecular mechanisms of DNA repair, recombination and mutagenesis. However, triplex formation utilizing guanine-rich oligonucleotides as third strands can be inhibited by potassium-induced self-association resulting in G-quadruplex formation. We report here that guanine… CONTINUE READING
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