Improved approach to identify cancer-associated autoantigens.

  title={Improved approach to identify cancer-associated autoantigens.},
  author={F{\'e}lix Fern{\'a}ndez Madrid and Naimei Tang and Huda Alansari and Robert L. Karvonen and John E. Tomkiel},
  journal={Autoimmunity reviews},
  volume={4 4},
The failure to identify biomarkers of clinical significance for cancer diagnosis and prognosis generated a great deal of skepticism in regard to the usefulness of autoantibody-based methods. SEREX was a major advancement in immunoscreening that resulted in the identification of a large group of autoantigens recognized by cancer sera. However, few SEREX-defined autoantigens have proven to have definitive diagnostic value in clinical practice. Often, the identified antigens are patient-specific… CONTINUE READING