Improved antibody-based ricin neutralization by affinity maturation is correlated with slower off-rate values.

@article{Rosenfeld2017ImprovedAR,
  title={Improved antibody-based ricin neutralization by affinity maturation is correlated with slower off-rate values.},
  author={Ronit Rosenfeld and Ron Alcalay and Adva Mechaly and Gideon Lapidoth and Eyal Epstein and Chanoch Kronman and Sarel J Fleishman and Ohad Mazor},
  journal={Protein engineering, design & selection : PEDS},
  year={2017},
  volume={30 9},
  pages={
          611-617
        }
}
While potent monoclonal antibodies against ricin were introduced over the years, the question whether increasing antibody affinity enables better toxin neutralization was not fully addressed yet. The aim of this study was to characterize the contribution of antibody affinity to the ricin neutralization potential of the antibody. cHD23 monoclonal antibody that targets the toxin B-subunit and interferes with its binding to membranal receptors, was isolated. In order to create antibody clones with… CONTINUE READING

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Affinity maturation of anti-ricin antibody

S. Olsnes, J. V. Kozlov
  • Curr. Top. Microbiol. Immunol.,
  • 2001
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