Improved anti-apoptotic and anti-remodeling potency of bone marrow mesenchymal stem cells by anoxic pre-conditioning in diabetic cardiomyopathy.

@article{Li2008ImprovedAA,
  title={Improved anti-apoptotic and anti-remodeling potency of bone marrow mesenchymal stem cells by anoxic pre-conditioning in diabetic cardiomyopathy.},
  author={J H Li and Nian Zhang and J A Wang},
  journal={Journal of endocrinological investigation},
  year={2008},
  volume={31 2},
  pages={103-10}
}
BACKGROUND Bone marrow mesenchymal stem cells (MSC) mediate their protection by paracrine mechanism under ischemic conditions and anoxic pre-conditioning (AP) of MSC strongly enhances their survival and regenerative capacity. However, there is no report about the therapeutic potency of MSC transplantation on diabetic cardiomyopathy (DCM), an important cause of heart failure. METHODS AND RESULTS Four months after streptozotocin injection, diabetic rats were randomly given an intramyocardial… CONTINUE READING
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