Improved antagonists of luteinizing hormone-releasing hormone modified in position 7.

Abstract

The structure-activity relationship of position 7 in the antagonist [N-Ac-D-Nal1,D-pClPhe2,D-Trp3,D-Arg6,D-Ala10]-LH-RH has been investigated by the incorporation of a series of amino acids at this position. The analogues were prepared by solid-phase peptide synthesis. All purifications were performed in two stages: gel permeation followed by preparative… (More)

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