Improved aerosolization performance of salbutamol sulfate formulated with lactose crystallized from binary mixtures of ethanol-acetone.

@article{Kaialy2011ImprovedAP,
  title={Improved aerosolization performance of salbutamol sulfate formulated with lactose crystallized from binary mixtures of ethanol-acetone.},
  author={Waseem Kaialy and Martyn David Ticehurst and John J. Murphy and Ali Nokhodchi},
  journal={Journal of pharmaceutical sciences},
  year={2011},
  volume={100 7},
  pages={2665-84}
}
It has been shown that dry powder inhaler (DPI) formulations typically achieve low fine particle fractions (poor performance). A commonly held theory is that this is due, at least in part, to low levels of detachment of drug from lactose during aerosolization as a result of strong adhesion of drug particles to the carrier surfaces. Therefore, the purpose of… CONTINUE READING