Improved adenovirus vectors for infection of cardiovascular tissues.

@article{Havenga2001ImprovedAV,
  title={Improved adenovirus vectors for infection of cardiovascular tissues.},
  author={Menzo Jans Emko Havenga and Angelique A. C. Lemckert and J. Grimbergen and Roland Jacobus Martinus Vogels and Linda G M Huisman and David Valerio and Abraham Bout and Paul H.A. Quax},
  journal={Journal of virology},
  year={2001},
  volume={75 7},
  pages={
          3335-42
        }
}
To identify improved adenovirus vectors for cardiovascular gene therapy, a library of adenovirus vectors based on adenovirus serotype 5 (Ad5) but carrying fiber molecules of other human serotypes, was generated. This library was tested for efficiency of infection of human primary vascular endothelial cells (ECs) and smooth muscle cells (SMCs). Based on luciferase, LacZ, or green fluorescent protein (GFP) marker gene expression, several fiber chimeric vectors were identified that displayed… CONTINUE READING
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