Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease

  title={Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease},
  author={A. Hughes and S. Daniel and A. Lees},
  pages={1497 - 1499}
The authors studied the accuracy of clinical diagnosis of idiopathic PD (IPD) in 100 consecutive clinically diagnosed cases that came to neuropathological examination. Ninety fulfilled pathologic criteria for IPD. Ten were misdiagnosed: multiple system atrophy (six), progressive supranuclear palsy (two), post-encephalitic parkinsonism (one), and vascular parkinsonism (one). Assessment of the clinical features suggests that an accuracy of 90% may be the highest that can be expected using current… Expand
The differential diagnosis of Parkinson's disease.
The diagnosis of Parkinson's disease continues to be challenging with misdiagnosis rates as high as 20-30% in early stages, largely due to failure to recognize atypical parkinsonian disorders including multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration and dementia with Lewy bodies. Expand
Clinical Manifestations of Parkinson's Disease and Parkinsonism
  • D. Hobson
  • Medicine, Psychology
  • Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • 2003
The clinical manifestations of Parkinson's disease and the main akinetic-rigid syndromes (progressive supranuclear palsy, multiple system atrophy, cortical-basal ganglionic degeneration, and dementia with Lewy bodies) that make up the differential diagnosis are summarized. Expand
Diagnosis and Differential Diagnosis of Parkinson’s Disease
Diagnostic criteria mainly focussing on the diagnosis of idiopathic Parkinson’s disease (iPD) are summarized and specific factors to differentiate this disorder from other disease entities are delineated. Expand
1 Diagnosis and Differential Diagnosis of Parkinson ’ s Disease
Parkinsonian syndromes are a heterogeneous entity of movement disorders, which can be subdivided into idiopathic Parkinson’s disease, rare genetic forms of Parkinson’s disease as well as symptomaticExpand
What features improve the accuracy of the clinical diagnosis of progressive supranuclear palsy‐parkinsonism (PSP‐P)?
  • D. Williams, A. Lees
  • Psychology, Medicine
  • Movement disorders : official journal of the Movement Disorder Society
  • 2010
Patients with PSP‐P shares many clinical features with PD and DLB, MSA and VP, but visual hallucinations, drug induced dyskinesias and autonomic dysfunction are very uncommon and may be helpful exclusion criteria. Expand
Alpha‐synuclein immunohistochemistry in two cases of co‐occurring idiopathic Parkinson's disease and motor neuron disease
Pathological analysis revealed the presence of Lewy bodies in brainstem nuclei and basal forebrain consistent with Lewy body disease (LBD), as well as motor neuron degeneration and argyrophilic grain disease. Expand
The Diagnosis of Parkinson’s Disease: Current Clinical Practice and Future Trends
The diagnosis of Parkinson’s disease relies on a thorough medical history and a detailed neurological examination, and dopamine markers are commonly used to detect the characteristic nigrostriatal impairment found in Parkinson's disease. Expand
Is Levodopa Response a Valid Indicator of Parkinson's Disease?
The aim was to test the diagnostic criterion of dopaminergic response by evaluating its association with pathologically confirmed diagnoses in a large population of parkinsonian patients. Expand
Diagnostic Criteria for Parkinson’s Disease: From James Parkinson to the Concept of Prodromal Disease
This paper critically re-appraise the main diagnostic criteria proposed for PD, with particular attention to the recently published criteria by the International Parkinson and Movement Disorder Society (MDS) task force, underlying their novelty and focusing on the diagnostic issues still open. Expand
Neuropathological correlates of parkinsonian disorders in a large Dutch autopsy series
Both a clinical diagnosis of Parkinson’s disease as well as MDS-PD criteria accurately predicted presence of LP in NBB donors, and LP was associated with more widespread amyloid-β pathology, suggesting a link between amyloids-β accumulation and LP formation. Expand


Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity. Expand
What features improve the accuracy of clinical diagnosis in Parkinson's disease: A clinicopathologic study
Assessment of clinical features of 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease suggests that studies based on consultant diagnosis of PD, using standard diagnostic criteria, will include cases other than PD, thus distorting results from clinical trials and epidemiologic studies. Expand
Diagnostic criteria for Parkinson disease.
A clinical diagnostic classification based on a comprehensive review of the literature regarding the sensitivity and specificity of the characteristic clinical features of PD is proposed: Definite, Probable, and Possible. Expand
Accuracy of clinical diagnosis in parkinsonism--a prospective study.
The correct clinical diagnosis in most non-IPD variants of PS was possible within 5 years of onset (range: 2 months to 18 years), and it is recommended that studies aimed at including only the IPD cases restrict the enrollment to those cases that have had PS motor manifestations for five years or longer duration. Expand
Criteria for diagnosing Parkinson's disease
This work proposes the following designated levels of confidence for the diagnosis of Parkinson's disease in its initial phases of clinical expression: (1) clinically possible, (2) clinically probable, and (3) clinically definite. Expand
Diagnostic criteria for Parkinson's disease
The diagnostic criteria used in current practice are by no means satisfactory, but cannot yet be replaced by new comprehensive criteria based on laboratory evidence. Expand
Accuracy of the clinical diagnoses of Lewy body disease, Parkinson disease, and dementia with Lewy bodies: a clinicopathologic study.
This study confirms features suggested to predict these disorders, except for the early presence of postural imbalance, which is not indicative of either disorder. Expand
The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.
  • W. Gibb, A. Lees
  • Medicine
  • Journal of neurology, neurosurgery, and psychiatry
  • 1988
Associated pathological findings suggest that cases of incidental Lewy body disease are presymptomatic cases of Parkinson's disease, and confirm the importance of age (time) in the evolution of the disease. Expand
Preliminary NINDS neuropathologic criteria for Steele‐Richardson‐Olszewski syndrome (progressive supranuclear palsy)
We present the preliminary neuropathologic criteria for progressive supranuclear palsy (PSP) as proposed at a workshop held at the National Institutes of Health, Bethesda, MD, April 24 and 25, 1993.Expand
Accuracy of the clinical diagnosis of Lewy body disease, Parkinson's disease, and dementia with Lewy bodies: a clinico-pathologic study
  • Arch Neurol
  • 1998