Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease

@article{Hughes2001ImprovedAO,
  title={Improved accuracy of clinical diagnosis of Lewy body Parkinson’s disease},
  author={A. Hughes and S. Daniel and A. Lees},
  journal={Neurology},
  year={2001},
  volume={57},
  pages={1497 - 1499}
}
The authors studied the accuracy of clinical diagnosis of idiopathic PD (IPD) in 100 consecutive clinically diagnosed cases that came to neuropathological examination. Ninety fulfilled pathologic criteria for IPD. Ten were misdiagnosed: multiple system atrophy (six), progressive supranuclear palsy (two), post-encephalitic parkinsonism (one), and vascular parkinsonism (one). Assessment of the clinical features suggests that an accuracy of 90% may be the highest that can be expected using current… Expand
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References

SHOWING 1-10 OF 12 REFERENCES
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.
TLDR
The pathological findings in 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease are reported, and these observations call into question current concepts of Parkinson's Disease as a single distinct morbid entity. Expand
What features improve the accuracy of clinical diagnosis in Parkinson's disease: A clinicopathologic study
TLDR
Assessment of clinical features of 100 patients diagnosed prospectively by a group of consultant neurologists as having idiopathic Parkinson's disease suggests that studies based on consultant diagnosis of PD, using standard diagnostic criteria, will include cases other than PD, thus distorting results from clinical trials and epidemiologic studies. Expand
Diagnostic criteria for Parkinson disease.
TLDR
A clinical diagnostic classification based on a comprehensive review of the literature regarding the sensitivity and specificity of the characteristic clinical features of PD is proposed: Definite, Probable, and Possible. Expand
Accuracy of clinical diagnosis in parkinsonism--a prospective study.
TLDR
The correct clinical diagnosis in most non-IPD variants of PS was possible within 5 years of onset (range: 2 months to 18 years), and it is recommended that studies aimed at including only the IPD cases restrict the enrollment to those cases that have had PS motor manifestations for five years or longer duration. Expand
Criteria for diagnosing Parkinson's disease
TLDR
This work proposes the following designated levels of confidence for the diagnosis of Parkinson's disease in its initial phases of clinical expression: (1) clinically possible, (2) clinically probable, and (3) clinically definite. Expand
Diagnostic criteria for Parkinson's disease
TLDR
The diagnostic criteria used in current practice are by no means satisfactory, but cannot yet be replaced by new comprehensive criteria based on laboratory evidence. Expand
Accuracy of the clinical diagnoses of Lewy body disease, Parkinson disease, and dementia with Lewy bodies: a clinicopathologic study.
TLDR
This study confirms features suggested to predict these disorders, except for the early presence of postural imbalance, which is not indicative of either disorder. Expand
The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.
  • W. Gibb, A. Lees
  • Medicine
  • Journal of neurology, neurosurgery, and psychiatry
  • 1988
TLDR
Associated pathological findings suggest that cases of incidental Lewy body disease are presymptomatic cases of Parkinson's disease, and confirm the importance of age (time) in the evolution of the disease. Expand
Preliminary NINDS neuropathologic criteria for Steele‐Richardson‐Olszewski syndrome (progressive supranuclear palsy)
We present the preliminary neuropathologic criteria for progressive supranuclear palsy (PSP) as proposed at a workshop held at the National Institutes of Health, Bethesda, MD, April 24 and 25, 1993.Expand
Accuracy of the clinical diagnosis of Lewy body disease, Parkinson's disease, and dementia with Lewy bodies: a clinico-pathologic study
  • Arch Neurol
  • 1998
...
1
2
...