Improved Visualization and Specific Binding for Metabotropic Glutamate Receptor Subtype 1 (mGluR1) Using [11C]ITMM with Ultra-High Specific Activity in Small-Animal PET

@inproceedings{Yamasaki2015ImprovedVA,
  title={Improved Visualization and Specific Binding for Metabotropic Glutamate Receptor Subtype 1 (mGluR1) Using [11C]ITMM with Ultra-High Specific Activity in Small-Animal PET},
  author={Tomoteru Yamasaki and Masayuki Fujinaga and Joji Yui and Hidekatsu Wakizaka and Tomoyuki Ohya and Nobuki Nengaki and Masanao Ogawa and Yoko Ikoma and Akiko Hatori and Lin Xie and Kazunori Kawamura and Ming-Rong Zhang and Suzie Chen},
  booktitle={PloS one},
  year={2015}
}
Metabotropic glutamate receptor subtype 1 (mGluR1) is a crucial target in the development of new medications to treat central nervous system (CNS) disorders. Recently, we developed N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-[11C]methoxy-N-methyl-benzamide ([11C]ITMM) as a useful positron emission tomography (PET) probe for mGluR1 in clinical studies. Here, we aimed to improve visualization and threshold of specific binding for mGluR1 using [11C]ITMM with ultra-high specific… CONTINUE READING

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