Improved Therapeutic Benefits by Combining Physical Cooling With Pharmacological Hypothermia After Severe Stroke in Rats

@inproceedings{Lee2016ImprovedTB,
  title={Improved Therapeutic Benefits by Combining Physical Cooling With Pharmacological Hypothermia After Severe Stroke in Rats},
  author={Jin Hwan Lee and Ling Wei and Xiaohuan Gu and Soonmi Won and Zheng Zachory Wei and Thomas A. Dix and Shan Ping Yu},
  booktitle={Stroke},
  year={2016}
}
BACKGROUND AND PURPOSE Therapeutic hypothermia is a promising strategy for treatment of acute stroke. Clinical translation of therapeutic hypothermia, however, has been hindered because of the lack of efficiency and adverse effects. We sought to enhance the clinical potential of therapeutic hypothermia by combining physical cooling (PC) with pharmacologically induced hypothermia after ischemic stroke. METHODS Wistar rats were subjected to 90-minute middle cerebral artery occlusion by… CONTINUE READING
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