Improved Testing for Microsatellite Instability in Colorectal Cancer Using a Simplified 3-Marker Assay

@article{Esemuede2010ImprovedTF,
  title={Improved Testing for Microsatellite Instability in Colorectal Cancer Using a Simplified 3-Marker Assay},
  author={Iyare O. Esemuede and Ann Forslund and Sajid A. Khan and L Qin and Mark I. Gimbel and Garrett M. Nash and Zhaoshi Zeng and MS ShoshanaRosenberg and Jinru Shia and Francis Barany and Philip B. Paty},
  journal={Annals of Surgical Oncology},
  year={2010},
  volume={17},
  pages={3370-3378}
}
In colorectal cancer (CRC), microsatellite instability (MSI) is a valuable marker of defective DNA mismatch repair that identifies cancers with distinct phenotypic properties, including favorable survival. However, the optimal assay for MSI status is unknown. We have evaluated a simplified 3-marker assay for MSI and compared it with the 5-marker (NCI) assay to see if technical variations in MSI testing are important. DNA samples from 357 CRCs were evaluated for MSI using the 5 microsatellite… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 23 references

Feasibility of screening for Lynch syndrome among patients with colorectal cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2008
View 3 Excerpts

Oxaliplatin, leucovorin, and fluorouracil with or without bevacizumab in treating patients who have undergone surgery for stage II colon

PJ O’Dwyer
Available: http://www. clinicaltrials.gov. Accessed • 2008
View 2 Excerpts

Chemotherapeutic implications in microsatellite unstable colorectal cancer.

Cancer biomarkers : section A of Disease markers • 2006
View 1 Excerpt

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