Improved Testing for Microsatellite Instability in Colorectal Cancer Using a Simplified 3-Marker Assay

  title={Improved Testing for Microsatellite Instability in Colorectal Cancer Using a Simplified 3-Marker Assay},
  author={Iyare O. Esemuede and Ann Forslund and Sajid A. Khan and L Qin and Mark I. Gimbel and Garrett M. Nash and Zhaoshi Zeng and MS ShoshanaRosenberg and Jinru Shia and Francis Barany and Philip B. Paty},
  journal={Annals of Surgical Oncology},
In colorectal cancer (CRC), microsatellite instability (MSI) is a valuable marker of defective DNA mismatch repair that identifies cancers with distinct phenotypic properties, including favorable survival. However, the optimal assay for MSI status is unknown. We have evaluated a simplified 3-marker assay for MSI and compared it with the 5-marker (NCI) assay to see if technical variations in MSI testing are important. DNA samples from 357 CRCs were evaluated for MSI using the 5 microsatellite… CONTINUE READING
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