Improved Survival with T Cell Clonotype Stability After Anti–CTLA-4 Treatment in Cancer Patients

@article{Cha2014ImprovedSW,
  title={Improved Survival with T Cell Clonotype Stability After Anti–CTLA-4 Treatment in Cancer Patients},
  author={Edward N. Cha and Mark B Klinger and Yafei Hou and Craig A. Cummings and Antoni Ribas and Malek Faham and Lawrence Fong},
  journal={Science Translational Medicine},
  year={2014},
  volume={6},
  pages={238ra70-238ra70}
}
Cytotoxic T lymphocyte–associated antigen-4 (CTLA-4) blockade can promote antitumor T cell immunity and clinical responses. The mechanism by which anti–CTLA-4 antibodies induces antitumor responses is controversial. To determine the effects of CTLA-4 blockade on the T cell repertoire, we used next-generation deep sequencing to measure the frequency of individual rearranged T cell receptor β (TCRβ) genes, thereby characterizing the diversity of rearrangements, known as T cell clonotypes. CTLA-4… CONTINUE READING
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