Improved Success of Sparse Matrix Protein Crystallization Screening with Heterogeneous Nucleating Agents

@article{Thakur2007ImprovedSO,
  title={Improved Success of Sparse Matrix Protein Crystallization Screening with Heterogeneous Nucleating Agents},
  author={Anil S. Thakur and Gautier Robin and Gregor Gun{\vc}ar and Neil F. W. Saunders and Janet Newman and Jennifer L. Martin and Bostjan Kobe},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={254 - 265}
}
BACKGROUND Crystallization is a major bottleneck in the process of macromolecular structure determination by X-ray crystallography. Successful crystallization requires the formation of nuclei and their subsequent growth to crystals of suitable size. Crystal growth generally occurs spontaneously in a supersaturated solution as a result of homogenous nucleation. However, in a typical sparse matrix screening experiment, precipitant and protein concentration are not sampled extensively, and… CONTINUE READING
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The interaction of proteins with solid surfaces

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