Improved Sensitivity of Nucleic Acid Database Searches Using Application-Specific Scoring Matrices

@inproceedings{States1991ImprovedSO,
  title={Improved Sensitivity of Nucleic Acid Database Searches Using Application-Specific Scoring Matrices},
  author={David J. States and Warren Gish and Stephen F. Altschul},
  year={1991}
}
Scoring matrices for nucleic acid sequence comparison that are based on models appropriate to the analysis of molecular sequencing errors or biological mutation processes are presented. In mammalian genomes, transition mutations occur significantly more frequently than transversions, and the optimal scoring of sequence alignments based on this substitution model differs from that derived assuming a uniform mutation model. The information from sequence alignments potentially available using an… CONTINUE READING

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