Improved Ribosome-Footprint and mRNA Measurements Provide Insights into Dynamics and Regulation of Yeast Translation.

@article{Weinberg2016ImprovedRA,
  title={Improved Ribosome-Footprint and mRNA Measurements Provide Insights into Dynamics and Regulation of Yeast Translation.},
  author={David E Weinberg and Premal Shah and Stephen W Eichhorn and Jeffrey A. Hussmann and Joshua B. Plotkin and David P. Bartel},
  journal={Cell reports},
  year={2016},
  volume={14 7},
  pages={1787-1799}
}
Ribosome-footprint profiling provides genome-wide snapshots of translation, but technical challenges can confound its analysis. Here, we use improved methods to obtain ribosome-footprint profiles and mRNA abundances that more faithfully reflect gene expression in Saccharomyces cerevisiae. Our results support proposals that both the beginning of coding regions and codons matching rare tRNAs are more slowly translated. They also indicate that emergent polypeptides with as few as three basic… CONTINUE READING
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