Improved Results Using Decellularized Human Valves for Children with Congenital Heart Defects

@article{Sylen2017ImprovedRU,
  title={Improved Results Using Decellularized Human Valves for Children with Congenital Heart Defects},
  author={Bahar S{\"o}ylen and Samir Sarikouch and Alex and er Horke},
  journal={Research and reviews: journal of nursing and health sciences},
  year={2017},
  volume={3},
  pages={1-4}
}
Operative mortality of children with congenital heart defects has decreased substantially in the past decade, thereby leading to increasing reoperations and increased valve replacement need. Within this article we want to summarize the mid-term clinical results of nonseeded decellularized homografts, deriving from donated human heart valves. So far, the most common therapeutic options for valve replacement in children have been either a biological valve replacement, which undergoes degenerative… 

Figures and Tables from this paper

Current Trends in Biomaterial Utilization for Cardiopulmonary System Regeneration

TLDR
This review also looks at details on new biological and synthetic biomaterials, tissue engineering, nanotechnology, and organ decellularization for cardiopulmonary regenerative therapies.

An Update on Congenital Heart Defectsin Humans (CHDs)

TLDR
Few of the causes that are responsible for the Congenital Heart Defects (CHDs), such as the 22q11.2 deletion, Disturbances in left-right patterning, Mutation in GDF1 gene, Maternal Obesity and SSRIs usage in maternity are discussed.

References

SHOWING 1-10 OF 17 REFERENCES

Decellularized fresh homografts for pulmonary valve replacement: a decade of clinical experience†

  • S. SarikouchA. Horke S. Cebotari
  • Medicine
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2016
TLDR
Mid-term results of DPH for PVR confirm earlier results of reduced re-operation rates compared with CH and BJV, and rate of freedom from explantation and peak trans-conduit gradient ≥50 mmHg was 86% for DPH, 64% for CH (n.s.) and 49% for BJV (P < 0.001).

Use of Fresh Decellularized Allografts for Pulmonary Valve Replacement May Reduce the Reoperation Rate in Children and Young Adults: Early Report

TLDR
Decellularized fresh allograft valves showed improved freedom from explantation, provided low gradients in follow-up, and exhibited adaptive growth in contrast to conventional homografteds and xenografts.

Decellularized aortic homografts for aortic valve and aorta ascendens replacement†

  • I. TudoracheA. Horke A. Haverich
  • Medicine
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2016
TLDR
DAHs withstand systemic circulation, provide outstanding EOA and appear as an alternative to conventional grafts for AVR in young patients as it avoids the use of any prosthetic material.

Early failure of the tissue engineered porcine heart valve SYNERGRAFT in pediatric patients.

  • P. SimonM. Kasimir E. Wolner
  • Medicine
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2003

Evaluation of 188 consecutive homografts implanted in pulmonary position after 20 years.

  • D. BoethigH. Goerler T. Breymann
  • Medicine
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
  • 2007

Bovine Jugular Veins versus Homografts in the Pulmonary Position: An Analysis across Two Centers and 711 Patients-Conventional Comparisons and Time Status Graphs as a New Approach.

TLDR
According to the time status graphs, the use of bovine jugular veins for RVOT in patients younger than 25 years appears to lead to superior results when compared with cryopreserved homografts.

Right ventricular outflow tract reconstruction: valved conduit of choice and clinical outcomes

TLDR
The pulmonary homograft is the most commonly used RVOT conduit, especially in small children, due to its excellent characteristics, and the newly-developed Contegra conduit has become populardue to its availability in full sizes and the acceptable results obtained at intermediate follow-up.

Homograft survival after tetralogy of Fallot repair: determinants of accelerated homograft degeneration.

TLDR
It is found that the gradient of the homograft 1 month after surgery is most indicative of accelerated Homograft degeneration, and it is hypothesized that mechanical, not immunological, factors play an important role in homografted degeneration.