Improved Prediction of In Vivo Peroral Absorption from In Vitro Intestinal Permeability Using an Internal Standard to Control for Intra- and Inter-Rat Variability

@article{Dowty1997ImprovedPO,
  title={Improved Prediction of In Vivo Peroral Absorption from In Vitro Intestinal Permeability Using an Internal Standard to Control for Intra- and Inter-Rat Variability},
  author={Martin E. Dowty and Charles R. Dietsch},
  journal={Pharmaceutical Research},
  year={1997},
  volume={14},
  pages={1792-1797}
}
Purpose. To evaluate the use of an in vitrointestinal permeability model to predict rat and human absorption as well as to evaluate the use of an internal standard to control for intra- and inter-rat variability. Methods. In vivoperoral absorption and in vitro steady-state intestinal permeability coefficients were determined in the rat for a variety of structurally different compounds with different physicochemical properties including: progesterone, hydrocortisone, salicylic acid, caffeine… CONTINUE READING

Similar Papers

Loading similar papers…