Improved Placement of Multi-mapping Small RNAs

  title={Improved Placement of Multi-mapping Small RNAs},
  author={Nathan R. Johnson and Jonathan M Yeoh and Ceyda Coruh and Michael J. Axtell},
High-throughput sequencing of small RNAs (sRNA-seq) is a popular method used to discover and annotate microRNAs (miRNAs), endogenous short interfering RNAs (siRNAs), and Piwi-associated RNAs (piRNAs). One of the key steps in sRNA-seq data analysis is alignment to a reference genome. sRNA-seq libraries often have a high proportion of reads that align to multiple genomic locations, which makes determining their true origins difficult. Commonly used sRNA-seq alignment methods result in either very… CONTINUE READING
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