Improved Pancreatic β-Cell Function in Type 2 Diabetic Patients After Lifestyle-Induced Weight Loss Is Related to Glucose-Dependent Insulinotropic Polypeptide

@inproceedings{Solomon2010ImprovedP,
  title={Improved Pancreatic β-Cell Function in Type 2 Diabetic Patients After Lifestyle-Induced Weight Loss Is Related to Glucose-Dependent Insulinotropic Polypeptide},
  author={Thomas P J Solomon and Jacob M Haus and Karen R. Kelly and Michael B Rocco and Sangeeta R. Kashyap and John P Kirwan},
  booktitle={Diabetes care},
  year={2010}
}
OBJECTIVE Restoration of insulin secretion is critical for the treatment of type 2 diabetes. Exercise and diet can alter glucose-induced insulin responses, but whether this is due to changes in beta-cell function per se is not clear. The mechanisms by which lifestyle intervention may modify insulin secretion in type 2 diabetes have also not been examined but may involve the incretin axis. RESEARCH DESIGN AND METHODS Twenty-nine older, obese (aged 65 +/- 1 years; BMI 33.6 +/- 1.0 kg/m(2… CONTINUE READING

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