Improved Ocular : Systemic Absorption Ratio of Timolol by Viscous Vehicle and Phenylephrine

@inproceedings{Kyyronen2005ImprovedO,
  title={Improved Ocular : Systemic Absorption Ratio of Timolol by Viscous Vehicle and Phenylephrine},
  author={Krisriino Kyyronen and Arro Urrri},
  year={2005}
}
  • Krisriino Kyyronen, Arro Urrri
  • Published 2005
Increasing the ocular absorption of timolol relative to its systemic absorption is important clinically because ophthalmic timolol may cause serious respiratory, cardiac, and central nervous system side effects. The authors evaluated the effects of phenylephrine coadministration and solution viscosity on the aqueous humonplasma and iris ciliary body:plasma ratios of peak timolol concentrations after ocular application. Timolol eye drops (5 my/ml, 25 n\) were administered to the eyes of… CONTINUE READING

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