Improved Muscle Function in Duchenne Muscular Dystrophy through L-Arginine and Metformin: An Investigator-Initiated, Open-Label, Single-Center, Proof-Of-Concept-Study.

@article{Hafner2016ImprovedMF,
  title={Improved Muscle Function in Duchenne Muscular Dystrophy through L-Arginine and Metformin: An Investigator-Initiated, Open-Label, Single-Center, Proof-Of-Concept-Study.},
  author={Patricia Hafner and Ulrike Bonati and Beat Erne and Maurice Schmid and Daniela Rubino and Urs Pohlman and Thomas Peters and E. Rutz and Stephan Frank and Cornelia Neuhaus and Stefanie Deuster and M. Gloor and Oliver Bieri and Arne Fischmann and Michael Sinnreich and Nuri Gueven and Dirk Fischer},
  journal={PloS one},
  year={2016},
  volume={11 1},
  pages={e0147634}
}
UNLABELLED Altered neuronal nitric oxide synthase function in Duchenne muscular dystrophy leads to impaired mitochondrial function which is thought to be one cause of muscle damage in this disease. The study tested if increased intramuscular nitric oxide concentration can improve mitochondrial energy metabolism in Duchenne muscular dystrophy using a novel therapeutic approach through the combination of L-arginine with metformin. Five ambulatory, genetically confirmed Duchenne muscular dystrophy… CONTINUE READING
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