Improved Meta-Analytic Methods Show No Effect of Chromium Supplements on Fasting Glucose

@article{Bailey2013ImprovedMM,
  title={Improved Meta-Analytic Methods Show No Effect of Chromium Supplements on Fasting Glucose},
  author={Christopher H Bailey},
  journal={Biological Trace Element Research},
  year={2013},
  volume={157},
  pages={1-8}
}
The trace mineral chromium has been extensively researched over the years in its role in glucose metabolism. Dietary supplement companies have attempted to make claims that chromium may be able to treat or prevent diabetes. Previous meta-analyses/systematic reviews have indicated that chromium supplementation results in a significant lowering of fasting glucose in diabetics but not in nondiabetics. A meta-analysis was conducted using an alternative measure of effect size, dppc2 in order to… 
[Chromium supplementation in patients with type 2 diabetes and high risk of type 2 diabetes: a meta-analysis of randomized controlled trials].
TLDR
The available evidence suggests favourable effects of chromium supplementation on glycaemic control in patients with diabetes, and this meta-analysis assesses the effects on metabolic profiles and safety ofchromium supplementation in type 2 diabetes mellitus and cholesterol.
Effect of Chromium Supplementation on Blood Glucose and Lipid Levels in Patients with Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis.
TLDR
The use of chromium supplements can reduce the glycosylated hemoglobin of type 1 diabetic patients to a certain extent, but it cannot effectively improve the fasting blood glucose and blood lipid levels of type 2 diabetic patients.
Chromium supplements for glycemic control in type 2 diabetes: limited evidence of effectiveness.
TLDR
On the basis of the low strength of existing evidence, chromium supplements have limited effectiveness, and there is little rationale to recommend their use for glycemic control in patients with existing T2DM.
Risk of Type 2 Diabetes Is Lower in US Adults Taking Chromium-Containing Supplements.
TLDR
Over one-half the adult US population consumes nutritional supplements, and over one-quarter consumes supplemental chromium, and the odds of having T2D were lower in those who, in the previous 30 d, had consumed supplements containing chromium.
CLINICAL EVIDENCE FOR CHROMIUM USE In 1997 , the intervention trial
TLDR
There is no evidence that supports advising patients with type 2 diabetes to take chromium supplements and future studies should focus on reliable methods to estimate chromium status to identify patients at risk for pathological alterations in their metabolism associated with chromium deficiency.
Chromium does not belong in the diabetes treatment arsenal: Current evidence and future perspectives.
TLDR
There is no evidence that supports advising patients with type 2 diabetes to take chromium supplements and future studies should focus on reliable methods to estimate chromium status to identify patients at risk for pathological alterations in their metabolism associated with chromium deficiency.
Chromium Supplementation Reduces Resting Heart Rate in Patients with Metabolic Syndrome and Impaired Glucose Tolerance
TLDR
Effect of Cr-enriched yeast on glucose, lipid metabolism, fat tissue hormones, oxidative stress, and DNA damage markers was analyzed and only resting heart rate was significantly reduced in patients treated by Cr yeast, reflecting reduced sympathetic activity.
Chromium supplements in health and disease
A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial
TLDR
Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects, which might open up new avenues in the prevention of diabetes.
The effects of dietary supplements and natural products targeting glucose levels: an overview.
TLDR
Although some dietary supplements and medicinal herbs showed a significant reduction in FBS and/or HbA1C, mostly their effects from the clinical point of view were not remarkable and further clinical trials are needed for making decision on anti-diabetic supplement efficacy.
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TLDR
A systematic review and meta-analysis of randomized clinical trials showed no association between chromium and glucose or insulin concentrations among nondiabetic subjects and data for persons with diabetes are inconclusive.
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TLDR
Chromium supplementation significantly improved glycemia among patients with diabetes and in people without diabetes, however, future studies that address the limitations in the current evidence are needed before definitive claims can be made about the effect of chromium supplementation.
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TLDR
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TLDR
Cr lowers FBS but does not affect HbA1c, lipids and BMI, and seven out of 13 relevant studies met the criteria and were included in the meta-analysis.
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TLDR
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TLDR
It is demonstrated that supplemental chromium had significant beneficial effects on HbA1c, glucose, insulin, and cholesterol variables in subjects with type 2 diabetes and was observed at levels higher than the upper limit of the Estimated Safe and Adequate Daily Dietary Intake.
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TLDR
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TLDR
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