Improved Meta-Analytic Methods Show No Effect of Chromium Supplements on Fasting Glucose

@article{Bailey2013ImprovedMM,
  title={Improved Meta-Analytic Methods Show No Effect of Chromium Supplements on Fasting Glucose},
  author={Christopher H Bailey},
  journal={Biological Trace Element Research},
  year={2013},
  volume={157},
  pages={1-8}
}
The trace mineral chromium has been extensively researched over the years in its role in glucose metabolism. Dietary supplement companies have attempted to make claims that chromium may be able to treat or prevent diabetes. Previous meta-analyses/systematic reviews have indicated that chromium supplementation results in a significant lowering of fasting glucose in diabetics but not in nondiabetics. A meta-analysis was conducted using an alternative measure of effect size, dppc2 in order to… Expand
[Chromium supplementation in patients with type 2 diabetes and high risk of type 2 diabetes: a meta-analysis of randomized controlled trials].
TLDR
The available evidence suggests favourable effects of chromium supplementation on glycaemic control in patients with diabetes, and this meta-analysis assesses the effects on metabolic profiles and safety ofchromium supplementation in type 2 diabetes mellitus and cholesterol. Expand
Effect of Chromium Supplementation on Blood Glucose and Lipid Levels in Patients with Type 2 Diabetes Mellitus: a Systematic Review and Meta-analysis.
TLDR
The use of chromium supplements can reduce the glycosylated hemoglobin of type 1 diabetic patients to a certain extent, but it cannot effectively improve the fasting blood glucose and blood lipid levels of type 2 diabetic patients. Expand
Chromium supplements for glycemic control in type 2 diabetes: limited evidence of effectiveness.
TLDR
On the basis of the low strength of existing evidence, chromium supplements have limited effectiveness, and there is little rationale to recommend their use for glycemic control in patients with existing T2DM. Expand
Risk of Type 2 Diabetes Is Lower in US Adults Taking Chromium-Containing Supplements.
TLDR
Over one-half the adult US population consumes nutritional supplements, and over one-quarter consumes supplemental chromium, and the odds of having T2D were lower in those who, in the previous 30 d, had consumed supplements containing chromium. Expand
CLINICAL EVIDENCE FOR CHROMIUM USE In 1997 , the intervention trial
Chromium is considered to have positive effects on insulin sensitivity and is marketed as an adjunctive therapy for inducing glucose tolerance in cases of insulin resistance (“the glucose toleranceExpand
Chromium does not belong in the diabetes treatment arsenal: Current evidence and future perspectives.
TLDR
There is no evidence that supports advising patients with type 2 diabetes to take chromium supplements and future studies should focus on reliable methods to estimate chromium status to identify patients at risk for pathological alterations in their metabolism associated with chromium deficiency. Expand
Chromium Supplementation Reduces Resting Heart Rate in Patients with Metabolic Syndrome and Impaired Glucose Tolerance
TLDR
Effect of Cr-enriched yeast on glucose, lipid metabolism, fat tissue hormones, oxidative stress, and DNA damage markers was analyzed and only resting heart rate was significantly reduced in patients treated by Cr yeast, reflecting reduced sympathetic activity. Expand
A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mass in Overweight or Obese Pre-Diabetic Subjects: A Randomized, Placebo-Controlled Trial
TLDR
Four-month treatment with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects, which might open up new avenues in the prevention of diabetes. Expand
Effects of Chromium Picolinate Supplementation on Control of Metabolic Variables: A Systematic Review
Chromium picolinate is widely used as a supplement to improve glucose metabolism, insulin sensitivity and lipid profile. Its actions, however, extend beyond these metabolic changes, as it hasExpand
Effects of Chromium Picolinate Supplementation on Cardiometabolic Biomarkers in Patients with Type 2 Diabetes Mellitus: a Randomized Clinical Trial
TLDR
In this study, oral supplementation with 400 µg CrPic for eight weeks did not alter FBG concentration as well as anthropometric parameters in individuals with T2DM, however, the modest beneficial effects of chromium supplementation on insulin resistance as indicated by HOMA-IR and lipid profile were found. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 50 REFERENCES
Glucose and insulin responses to dietary chromium supplements: a meta-analysis.
TLDR
A systematic review and meta-analysis of randomized clinical trials showed no association between chromium and glucose or insulin concentrations among nondiabetic subjects and data for persons with diabetes are inconclusive. Expand
Effect of Chromium Supplementation on Glucose Metabolism and Lipids: A Systematic Review of Randomized Controlled Trials
TLDR
Chromium supplementation significantly improved glycemia among patients with diabetes and in people without diabetes, however, future studies that address the limitations in the current evidence are needed before definitive claims can be made about the effect of chromium supplementation. Expand
Effect of Chromium Supplementation on Glucose Metabolism and Lipids
TLDR
Chromium supplementation significantly improved glycemia among patients with diabetes and in people without diabetes, however, future studies that address the limitations in the current evidence are needed before definitive claims can be made about the effect of chromium supplementation. Expand
Effect of chromium on glucose and lipid profiles in patients with type 2 diabetes; a meta-analysis review of randomized trials.
  • M. Abdollahi, A. Farshchi, S. Nikfar, M. Seyedifar
  • Medicine
  • Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  • 2013
TLDR
Cr lowers FBS but does not affect HbA1c, lipids and BMI, and seven out of 13 relevant studies met the criteria and were included in the meta-analysis. Expand
Chromium Treatment Has No Effect in Patients With Type 2 Diabetes in a Western Population
TLDR
There is no evidence that chromium in the form of chromium yeast is effective in improving glycemic control in Western patients with type 2 diabetes who are taking oral hypoglycemic agents. Expand
Effects of chromium supplementation on fasting insulin levels and lipid parameters in healthy, non-obese young subjects.
TLDR
Those individuals within the chromium group with initial fasting IRI levels greater than 35 pmol/l had a significant decrease in IRI level after supplementation (P < 0.03) despite no significant changes in serum lipids, and may benefit from chromium supplementation by improving insulin sensitivity and cardiovascular risk over time. Expand
Elevated Intakes of Supplemental Chromium Improve Glucose and Insulin Variables in Individuals With Type 2 Diabetes
TLDR
It is demonstrated that supplemental chromium had significant beneficial effects on HbA1c, glucose, insulin, and cholesterol variables in subjects with type 2 diabetes and was observed at levels higher than the upper limit of the Estimated Safe and Adequate Daily Dietary Intake. Expand
Chromium picolinate does not improve key features of metabolic syndrome in obese nondiabetic adults.
TLDR
CrPic at 1000 microg/day does not improve key features of the metabolic syndrome in obese nondiabetic patients and has no significant effect on other measures of glucose metabolism, body weight, serum lipids, or measures of inflammation and oxidative stress. Expand
In patients with HIV-infection, chromium supplementation improves insulin resistance and other metabolic abnormalities: a randomized, double-blind, placebo controlled trial.
TLDR
It is suggested that chromium supplements alleviate some of the antiretroviral-associated metabolic abnormalities in HIV+ patients, and body weight and medication profile remained stable throughout the study for both groups. Expand
Dietary chromium and effect of chromium supplementation on glucose tolerance of elderly Canadian women
TLDR
No clear cut effects of chromium supplementation on glucose tolerance or serum insulin values were observed in these women, but non-medicated subjects at risk of impaired glucose tolerance showed a significant (p=0.03) mean decrease in 2 hour glucose values afterchromium supplementation. Expand
...
1
2
3
4
5
...