Improved Lung Concentration of Levofloxacin by Targeted Gelatin Microspheres: In Vivo Pharmacokinetic Evaluation of Intake Rate, Targeting Efficacy Parameters and Peak Concentration Ratio in Albino Mice


High dosage and repeated ingestion of antibiotics in the treatment of pneumonia lead to inappropriate disposition of the drug and thus increase undesirable effects. Hence, this study was intended to achieve high levofloxacin concentration in lungs by targeted levofloxacin gelatin microspheres (LGMs). The optimized LGM prepared by emulsion method was… (More)
DOI: 10.1007/s12247-016-9252-y

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