Improved HPLC determination of fluoxetine and norfluoxetine in human plasma

@article{Raggi1999ImprovedHD,
  title={Improved HPLC determination of fluoxetine and norfluoxetine in human plasma},
  author={Meri Raggi and Roberto Mandrioli and G. Casamenti and V. Volterra and Claudia Desiderio and Salvatore Fanali},
  journal={Chromatographia},
  year={1999},
  volume={50},
  pages={423-427}
}
SummaryAn HPLC method with fluorescence detection has been developed for the determination of fluoxetine and its main metabolite norfluoxetine in human plasma. Pretreatment of the biological samples by liquid-liquid extraction was used to improve the sensitivity of a previously published SPE procedure. The method uses 200 μL plasma and recovery is good for both analytes. On a C8 column with a mixture of perchlorate buffer and acetonitrile as mobile phase fluoxetine, norfluoxetine and the… CONTINUE READING

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