Improved ELISA for determination of anti-diphtheria and/or anti-tetanus antitoxin antibodies in sera.

@article{Kristiansen1997ImprovedEF,
  title={Improved ELISA for determination of anti-diphtheria and/or anti-tetanus antitoxin antibodies in sera.},
  author={Max Kristiansen and Henrik Aggerbeck and I. D. Heron},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  year={1997},
  volume={105 11},
  pages={843-53}
}
Double-antigen ELISAs for detection and quantification of anti-tetanus or anti-diphtheria antibodies in serum have been developed. The assays showed good correlations with established toxin neutralizing assays and were functionally specific for IgG antibodies. The double-antigen set-up allows specific antibodies to bind to antigen-coated microtitre wells with one arm and the free arm to bind to biotin-labelled antigen. The amount of antibodies able to bind labelled antigen was assessed by… CONTINUE READING

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